Article
A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement.
European journal of endocrinology - 1 May 2011
Taylor Peter N, Panicker Vijay, Sayers Adrian, Shields Beverley, Iqbal Ahmed, Bremner Alexandra P, Beilby John P, Leedman Peter J, Hattersley Andrew T, Vaidya Bijay, Frayling Timothy, Evans Jonathan, Tobias Jonathan H, Timpson Nicholas J, Walsh John P, Dayan Colin M
Abstract excerpt
OBJECTIVE: Common variants in PDE8B are associated with TSH but apparently without any effect on thyroid hormone levels that is difficult to explain. Furthermore, the stability of the association has not been examined in longitudinal studies or in patients on levothyroxine (l-T(4)). DESIGN: Totally, four cohorts were used (n=2557): the Busselton Health Study (thyroid function measured on two occasions), DEPTH,...
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