Article
Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction.
PloS one - 1 Jan 2026
Hu Yilang, Hu Hong, Xu Lijun, Tang Xuzheng, Wang Chongyu, Lian Zhengyi, Xie Chenyu, Xie Zhiwan, Wang Qingqing
Abstract excerpt
OBJECTIVE: Hyperthyroidism and hypothyroidism are globally prevalent endocrine disorders, with their pathogenesis involving multifactorial mechanisms including genetics, immunity, and metabolism. Although genome-wide association studies (GWAS) have identified risk genes such as PDE8B, critical gaps remain in the annotation of causal variants in non-coding regions, characterization of tissue-specific regulatory...
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