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Article

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

3 Mar 2011

Abstract excerpt

During endochondral bone formation, Sox9 expression starts in mesenchymal progenitors, continues in the round and flat chondrocyte stages at high levels, and ceases just prior to the hypertrophic chondrocyte stage. Sox9 is important in mesenchymal progenitors for their differentiation into chondrocytes, but its functions post-differentiation have not been determined. To investigate Sox9 function in chondrocytes,...

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PMID: 21367821
DOI: 10.1242/dev.057802

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Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathwaysPMID 21367821Read ↗

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SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.Semantic proximity Read ↗

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