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Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation

12 Feb 2024

Abstract excerpt

SOX8 was linked in a genome-wide association study to human height heritability, but roles in chondrocytes for this close relative of the master chondrogenic transcription factor SOX9 remain unknown. We undertook here to fill this knowledge gap. High-throughput assays demonstrate expression of human SOX8 and mouse Sox8 in growth plate cartilage. In situ assays show that Sox8 is expressed at a similar level as...

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Identifiers

PMID: 38346197
DOI: 10.1073/pnas.2316969121

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Research trail→

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Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferationPMID 38346197Read ↗

SOX9 and the many facets of its regulation in the chondrocyte lineageSemantic proximity Read ↗

Dominance of SOX9 function over RUNX2 during skeletogenesisSemantic proximity Read ↗

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian ChondrocyteSemantic proximity Read ↗

Chondrogenic Enhancer Landscape of Limb and Axial Skeleton DevelopmentSemantic proximity Read ↗

The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones.Semantic proximity Read ↗

Brief Report: Importance of SOX8 for In Vitro Chondrogenic Differentiation of Human Mesenchymal Stromal CellsSemantic proximity Read ↗

Human growth plates house resting zone sub-populations with features of quiescent stem cellsSemantic proximity Read ↗

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossificationSemantic proximity Read ↗

Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasiaSemantic proximity Read ↗

SOX9 in cartilage development and diseaseSemantic proximity Read ↗

Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zoneSemantic proximity Read ↗

Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes.Semantic proximity Read ↗

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