Article
SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.
PLoS genetics - 1 Nov 2011
Leung Victor Y L, Gao Bo, Leung Keith K H, Melhado Ian G, Wynn Sarah L, Au Tiffany Y K, Dung Nelson W F, Lau James Y B, Mak Angel C Y, Chan Danny, Cheah Kathryn S E
Abstract excerpt
Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state. The restricted and reciprocal expression of the collagen X gene, Col10a1, in hypertrophic chondrocytes and Sox9 in immature chondrocytes epitomise the precise spatiotemporal control of gene expression as chondrocytes progress through phases of...
Topics
- Animals
- Base Sequence
- Bone Development
- Cartilage
- Cell Differentiation
- Chondrocytes
- Chondrogenesis
- Collagen Type II
- Collagen Type X
- Enhancer Elements, Genetic