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Article

SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.

PLoS genetics - 1 Nov 2011

Leung Victor Y L, Gao Bo, Leung Keith K H, Melhado Ian G, Wynn Sarah L, Au Tiffany Y K, Dung Nelson W F, Lau James Y B, Mak Angel C Y, Chan Danny, Cheah Kathryn S E

Abstract excerpt

Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state. The restricted and reciprocal expression of the collagen X gene, Col10a1, in hypertrophic chondrocytes and Sox9 in immature chondrocytes epitomise the precise spatiotemporal control of gene expression as chondrocytes progress through phases of...

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Share to Bone Development
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22072985
DOI: 10.1371/journal.pgen.1002356
PMCID: PMC3207907

Genes

SOX9
GLI2
GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.PMID 22072985Read ↗

Identification of SOX9 Interaction Sites in the Genome of ChondrocytesSemantic proximity Read ↗

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian ChondrocyteSemantic proximity Read ↗

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.Semantic proximity Read ↗

Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiationSemantic proximity Read ↗

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossificationSemantic proximity Read ↗

Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte–specific expression in vivoSemantic proximity Read ↗

Brief Report: Importance of SOX8 for In Vitro Chondrogenic Differentiation of Human Mesenchymal Stromal CellsSemantic proximity Read ↗

Regulation of Cartilage Development and Diseases by Transcription FactorsSemantic proximity Read ↗

SOX9 and the many facets of its regulation in the chondrocyte lineageSemantic proximity Read ↗

Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements.Semantic proximity Read ↗

Sox9 is required for cartilage formation.Semantic proximity Read ↗

Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer.Semantic proximity Read ↗

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