MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins

Abstract excerpt

Intracellular signal transduction networks involving protein kinases are important modulators of cell survival and cell death in multicellular organisms. Functional compromise of these networks has been linked to aberrant apoptosis in diseases such as cancer. To identify novel kinase regulators of cell death, we conducted an RNAi-based screen to identify modulators of the intrinsic apoptosis pathway. Using this...

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• Autophagy in Disease and Therapy
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