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Article

Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1.

PloS one - 1 Jan 2012

Thomas Luke W, Lam Connie, Clark Richard E, White Michael R H, Spiller David G, Moots Robert J, Edwards Steven W

Abstract excerpt

Mcl-1 is an anti-apoptotic member of the Bcl-2 family that plays a key role in normal development, but also in pathologies such as cancer. It has some unusual properties compared to other anti-apoptotic members of the Bcl-2 family, and its expression and function are dynamically regulated by a variety of post-transcriptional and post-translational processes. Of note, Mcl-1 protein has a very short half life, and...

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Identifiers

PMID: 23024798
DOI: 10.1371/journal.pone.0045088
PMCID: PMC3443205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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