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Article

Phosphorylation alters Bim-mediated Mcl-1 stabilization and priming.

The FEBS journal - 1 Jul 2018

Conage-Pough Jason E, Boise Lawrence H

Abstract excerpt

Mcl-1 is a highly labile protein, subject to extensive post-translational regulation. This distinguishes Mcl-1 from other antiapoptotic proteins and necessitates further study to better understand how interactions with proapoptotic Bcl-2 proteins affect its regulation. One such protein, Bim, is known to stabilize Mcl-1, and Bim phosphorylation has been associated with increased Mcl-1 binding. Consequently, we...

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Identifiers

PMID: 29775995
DOI: 10.1111/febs.14505
PMCID: PMC6215700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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