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Article

Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.

The Journal of biological chemistry - 22 Apr 2011

Qu Xiuxia, Carbe Christian, Tao Chenqi, Powers Andrea, Lawrence Roger, van Kuppevelt Toin H, Cardoso Wellington V, Grobe Kay, Esko Jeffrey D, Zhang Xin

Abstract excerpt

Heparan sulfate, an extensively sulfated glycosaminoglycan abundant on cell surface proteoglycans, regulates intercellular signaling through its binding to various growth factors and receptors. In the lacrimal gland, branching morphogenesis depends on the interaction of heparan sulfate with Fgf10-Fgfr2b. To address if lacrimal gland development and FGF signaling depends on 2-O-sulfation of uronic acids and...

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Identifiers

PMID: 21357686
DOI: 10.1074/jbc.M111.225003
PMCID: PMC3077643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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