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Article

Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction.

Development (Cambridge, England) - 1 Jan 2008

Pan Yi, Carbe Christian, Powers Andrea, Zhang Eric E, Esko Jeffrey D, Grobe Kay, Feng Gen-Sheng, Zhang Xin

Abstract excerpt

Preferential outgrowth of the bud cells forms the basis of branching morphogenesis. Here, we show that lacrimal gland development requires specific modification of heparan sulfates by Ndst genes at the tip of the lacrimal gland bud. Systemic and conditional knockout experiments demonstrate the tissue specific requirement of Ndst1 and Ndst2 in the lacrimal gland epithelial, but not mesenchymal, cells, and the...

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Identifiers

PMID: 18077586
DOI: 10.1242/dev.014829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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