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Article

Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem cells for malignant transformation

23 Apr 2015

Abstract excerpt

Recent investigations indicate that epigenetic regulators act at the initial step of myeloid leukemogenesis by forming preleukemic hematopoietic stem cells (HSCs), which possess the increased self-renewal potential but retain multidifferentiation ability, and synergize with genetic abnormalities in later stages to develop full-blown acute myeloid leukemias. However, it is still unknown whether this theory is...

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Share to Epigenetics and DNA Methylation
Share to Hematopoietic Stem Cell Transplantation
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PMID: 25904247
DOI: 10.1182/blood-2014-11-610907

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