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Article

Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains.

Diabetes - 1 Jul 2003

Bergman Marie-Louise, Duarte Nadia, Campino Susana, Lundholm Marie, Motta Vinicius, Lejon Kristina, Penha-Gonçalves Carlos, Holmberg Dan

Abstract excerpt

Type 1 diabetes in the nonobese diabetic (NOD) mouse is a multifactorial and polygenic disease. The NOD-derived genetic factors that contribute to type 1 diabetes are named Idd (insulin-dependent diabetes) loci. To date, the biological functions of the majority of the Idd loci remain unknown. We have previously reported that resistance of NOD immature thymocytes to depletion by dexamethazone (Dxm) maps to the...

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PMID: 12829632
DOI: 10.2337/diabetes.52.7.1677

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Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains.PMID 12829632Read ↗

Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6.Semantic proximity Read ↗

Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region.Semantic proximity Read ↗

A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.Semantic proximity Read ↗

Low rate of proliferation in immature thymocytes of the non-obese diabetic mouse maps to the Idd6 diabetes susceptibility region.Semantic proximity Read ↗

The Idd6.2 diabetes susceptibility region controls defective expression of the Lrmp gene in nonobese diabetic (NOD) mice.Semantic proximity Read ↗

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.Semantic proximity Read ↗

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Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses.Semantic proximity Read ↗

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