Article
Osteoblast-targeted overexpression of PPARγ inhibited bone mass gain in male mice and accelerated ovariectomy-induced bone loss in female mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2011
Cho Sun Wook, Yang Jae-Yeon, Her Sun Ju, Choi Hyung Jin, Jung Ju Yeon, Sun Hyun Jin, An Jee Hyun, Cho Hwa Young, Kim Sang Wan, Park Kyong Soo, Kim Seong Yeon, Baek Wook-Young, Kim Jung-Eun, Yim Mijung, Shin Chan Soo
Abstract excerpt
PPARγ has critical role in the differentiation of mesenchymal stem cells into adipocytes while suppressing osteoblastic differentiation. We generated transgenic mice that overexpress PPARγ specifically in osteoblasts under the control of a 2.3-kb procollagen type 1 promoter (Col.1-PPARγ). Bone mineral density (BMD) of 6- to 14-week-old Col.1 - PPARγ male mice was 8% to 10% lower than that of their wild-type...
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