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Article

Increased marrow adipogenesis does not contribute to age‐dependent appendicular bone loss in female mice

13 Oct 2020

Abstract excerpt

Marrow adipocytes and osteoblasts differentiate from common mesenchymal progenitors in a mutually exclusive manner, and diversion of these progenitors toward adipocytes in old age has been proposed to account for the decline in osteoblasts and the development of involutional osteoporosis. This idea has been supported by evidence that thiazolidinedione (TZD)-induced activation of PPARγ, the transcription factor...

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PMID: 33048436
DOI: 10.1111/acel.13247

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