Article
PPARβ/δ governs Wnt signaling and bone turnover.
Nature medicine - 1 May 2013
Scholtysek Carina, Katzenbeisser Julia, Fu He, Uderhardt Stefan, Ipseiz Natacha, Stoll Cornelia, Zaiss Mario M, Stock Michael, Donhauser Laura, Böhm Christina, Kleyer Arnd, Hess Andreas, Engelke Klaus, David Jean-Pierre, Djouad Farida, Tuckermann Jan Peter, Desvergne Béatrice, Schett Georg, Krönke Gerhard
Abstract excerpt
Peroxisome proliferator-activated receptors (PPARs) act as metabolic sensors and central regulators of fat and glucose homeostasis. Furthermore, PPARγ has been implicated as major catabolic regulator of bone mass in mice and humans. However, a potential involvement of other PPAR subtypes in the regulation of bone homeostasis has remained elusive. Here we report a previously unrecognized role of PPARβ/δ as a key...
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