Association of cartilage‐specific deletion of peroxisome proliferator–activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model

Abstract excerpt

OBJECTIVE: Long bones develop through the strictly regulated process of endochondral ossification within the growth plate, resulting in the replacement of cartilage by bone. Defects in this process can result in skeletal abnormalities and a predisposition to degenerative joint diseases such as osteoarthritis (OA). Studies suggest that activation of the transcription factor peroxisome proliferator-activated...

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