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Article

Expression of Insulinoma-Associated 2 (INSM2) in Pancreatic Islet Cells Is Regulated by the Transcription Factors Ngn3 and NeuroD1

22 Feb 2011

Abstract excerpt

The insulinoma-associated 2 (Insm2) gene is a member of the Snail/Gfi1/Insm1 transcriptional repressor superfamily. However, little is known about how the expression of human INSM2 or mouse Insm2 in neuroendocrine tissues is regulated. Here we report the expression of INSM2/Insm2 in human fetal pancreas and mouse embryos, as well as adult pancreatic islets, and its regulation by two major islet transcription...

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Identifiers

PMID: 21343251
DOI: 10.1210/en.2010-1065

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Related research

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Research trail→

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Expression of Insulinoma-Associated 2 (INSM2) in Pancreatic Islet Cells Is Regulated by the Transcription Factors Ngn3 and NeuroD1PMID 21343251Read ↗

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Distinct Gene Expression Programs Function in Progenitor and Mature Islet CellsSemantic proximity Read ↗

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PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regenerationSemantic proximity Read ↗

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The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcriptionSemantic proximity Read ↗

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