Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulinoma-Associated-1: From Neuroendocrine Tumor Marker to Cancer Therapeutics

21 May 2019

Abstract excerpt

Abstract Insulinoma-associated-1 (IA-1 or INSM1) encodes a zinc-finger transcription factor, which was isolated from a human insulinoma subtraction library, with specific expression patterns, predominantly in developing neuroendocrine tissues and tumors. INSM1 is key in early pancreatic endocrine, sympatho-adrenal lineage, and pan-neurogenic precursor development. Insm1 gene ablation results in impairment of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroblastoma Research and Treatments
Share to Neuroendocrine Tumor Research Advances
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31113827
DOI: 10.1158/1541-7786.mcr-19-0286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulinoma-Associated-1: From Neuroendocrine Tumor Marker to Cancer TherapeuticsPMID 31113827Read ↗

INSM1 Regulates Neuroendocrine Plasticity and Tumor Progression in Prostate CancerSemantic proximity Read ↗

The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses β- to δ-Cell Transdifferentiation.Semantic proximity Read ↗

Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequenceSemantic proximity Read ↗

Tracing Early Molecular Drivers of Gastrinoma in MEN1: A Systematic Review for Precision Surveillance and Improved Patient OutcomesSemantic proximity Read ↗

Cancer Cells Retrace a Stepwise Differentiation Program during Malignant ProgressionSemantic proximity Read ↗

Pancreatic Neuroendocrine Neoplasms in Multiple Endocrine Neoplasia Type 1Semantic proximity Read ↗

Transcriptomic profiling of insulinomas reveals a new "low-endocrine" subtype with low YY1 expressions.Semantic proximity Read ↗

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.Semantic proximity Read ↗

Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic RegulationSemantic proximity Read ↗

Implications of noncoding regulatory functions in the development of insulinomas.Semantic proximity Read ↗

A novel human insulinoma-associated cDNA, IA-1, encodes a protein with “zinc-finger” DNA-binding motifs.Semantic proximity Read ↗

Second-Generation Neuroendocrine Immunohistochemical Markers: Reflections from Clinical ImplementationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.