Article
Genetics of ACPA-positive rheumatoid arthritis: the beginning of the end?
Annals of the rheumatic diseases - 1 Mar 2011
de Vries René R P, van der Woude Diane, Houwing Jeanine J, Toes Rene E M
Abstract excerpt
Heritability is a measure for the contribution of genetic variation to the variation in liability to disease and for rheumatoid arthritis (RA) had previously been estimated to be about 60%. This has been recently confirmed and could show that the heritability of anti-citrullinated protein autoantibody (ACPA)-positive and ACPA-negative RA is similar. Apart from gender, the main known genetic factor is HLA, and its...
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