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Article

The status of the terminal regions of α-synuclein in different forms of aggregates during fibrillization.

International journal of biological macromolecules - 15 Jul 2020

Marvian Amir Tayaranian, Aliakbari Farhang, Mohammad-Beigi Hossein, Ahmadi Zeinab Alsadat, Mehrpooyan Sina, Lermyte Frederik, Nasouti Mahour, Collingwood Joanna F, Otzen Daniel E, Morshedi Dina

Abstract excerpt

The α-synuclein (αSN) amyloid fibrillization process is known to be a crucial phenomenon associated with neuronal loss in various neurodegenerative diseases, most famously Parkinson's disease. The process involves different aggregated species and ultimately leads to formation of β-sheet rich fibrillar structures. Despite the essential role of αSN aggregation in the pathoetiology of various neurological disorders,...

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PMID: 32240735
DOI: 10.1016/j.ijbiomac.2020.03.238

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