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Article

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015

Velarde Michael C, Demaria Marco, Melov Simon, Campisi Judith

Abstract excerpt

Tissue homeostasis declines with age partly because stem/progenitor cells fail to self-renew or differentiate. Because mitochondrial damage can accelerate aging, we tested the hypothesis that mitochondrial dysfunction impairs stem cell renewal or function. We developed a mouse model, Tg(KRT14-cre/Esr1) (20Efu/J) × Sod2 (tm1Smel) , that generates mitochondrial oxidative stress in keratin 14-expressing epidermal...

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Source

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Identifiers

PMID: 26240345
DOI: 10.1073/pnas.1505675112
PMCID: PMC4547253

Genes

KRT14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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