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Article

The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

7 Apr 2009

Abstract excerpt

The carboxyterminal region of activation-induced deaminase (AID) is required for its function in Ig class switch recombination (CSR) and also contains a nuclear-export sequence (NES). Here, based on an extensive fine-structure mutation analysis of the AID NES, as well as from AID chimeras bearing heterologous NESs, we show that while a functional NES is indeed essential for CSR, it is not sufficient. The precise...

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Identifiers

PMID: 19351893
DOI: 10.1073/pnas.0810808106

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The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequencePMID 19351893Read ↗

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Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination.Semantic proximity Read ↗

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