Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.

Autophagy - 1 Jun 2011

Bartlett Bryan J, Isakson Pauline, Lewerenz Jan, Sanchez Heriberto, Kotzebue Roxanne W, Cumming Robert C, Harris Greg L, Nezis Ioannis P, Schubert David R, Simonsen Anne, Finley Kim D

Abstract excerpt

Suppression of macroautophagy, due to mutations or through processes linked to aging, results in the accumulation of cytoplasmic substrates that are normally eliminated by the pathway. This is a significant problem in long-lived cells like neurons, where pathway defects can result in the accumulation of aggregates containing ubiquitinated proteins. The p62/Ref(2)P family of proteins is involved in the autophagic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy

Share to Cytoplasm

Share to Detergents

Share to Drosophila Proteins

Share to Microscopy, Electron, Transmission

Share to Sequestosome-1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 21325881
DOI: 10.4161/auto.7.6.14943
PMCID: PMC3127048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.PMID 21325881Read ↗

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain.Semantic proximity Read ↗

Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged DrosophilaSemantic proximity Read ↗

Protein recycling pathways in neurodegenerative diseasesSemantic proximity Read ↗

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult DrosophilaSemantic proximity Read ↗

Proteasome dysfunction in<i>Drosophila</i>signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature agingSemantic proximity Read ↗

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampusSemantic proximity Read ↗

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal deathSemantic proximity Read ↗

<i>Drosophila</i> p38 MAPK Interacts with BAG-3/starvin to Regulate Age-dependent Protein HomeostasisSemantic proximity Read ↗

Evaluating age-associated phenotypes in a mouse model of protein dyshomeostasis.Semantic proximity Read ↗

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants.Semantic proximity Read ↗

Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes.Semantic proximity Read ↗

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.