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Article

Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes.

PLoS genetics - 1 Mar 2021

Liu Xuezhao, Yin Limin, Li Tianyou, Lin Lingxi, Zhang Jie, Li Yang

Abstract excerpt

Neurodegenerative diseases are characterized by neuron loss and accumulation of undegraded protein aggregates. These phenotypes are partially due to defective protein degradation in neuronal cells. Autophagic clearance of aggregated proteins is critical to protein quality control, but the underlying mechanisms are still poorly understood. Here we report the essential role of WDR81 in autophagic clearance of...

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Identifiers

PMID: 33730050
DOI: 10.1371/journal.pgen.1009415
PMCID: PMC7968681

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