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Protein recycling pathways in neurodegenerative diseases

1 Jan 2014

Abstract excerpt

Many progressive neurodegenerative diseases, including Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and frontotemporal lobe dementia, are associated with the formation of insoluble intracellular proteinaceous inclusions. It is therefore imperative to understand the factors that regulate normal, as well as abnormal, protein recycling in neurons. Dysfunction of the...

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PMID: 25031631
DOI: 10.1186/alzrt243

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