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Article

Proteasome dysfunction in<i>Drosophila</i>signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

5 Jun 2013

Abstract excerpt

The ubiquitin-proteasome system is central to the regulation of cellular proteostasis. Nevertheless, the impact of in vivo proteasome dysfunction on the proteostasis networks and the aging processes remains poorly understood. We found that RNAi-mediated knockdown of 20S proteasome subunits in Drosophila melanogaster resulted in larval lethality. We therefore studied the molecular effects of proteasome dysfunction...

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PMID: 23738891
DOI: 10.1111/acel.12111

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