Article

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

2018-03-14

Abstract excerpt

Mutations in the autophagy gene WDR45 cause β-propeller protein-associated neurodegeneration (BPAN); however the molecular and cellular mechanism of the disease process is largely unknown. Here we generated constitutive Wdr45 knockout (KO) mice that displayed cognitive impairments, abnormal synaptic transmission and lesions in hippocampus and basal ganglia. Immunohistochemistry analysis shows loss of neurons in...

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Literature Corpus work: f487f078-d3ed-53d4-aed5-6f36b5ffb585
DOI: 10.1101/282210

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