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Article

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain.

The Journal of cell biology - 24 Mar 2008

Nezis Ioannis P, Simonsen Anne, Sagona Antonia P, Finley Kim, Gaumer Sébastien, Contamine Didier, Rusten Tor Erik, Stenmark Harald, Brech Andreas

Abstract excerpt

P62 has been proposed to mark ubiquitinated protein bodies for autophagic degradation. We report that the Drosophila melanogaster p62 orthologue, Ref(2)P, is a regulator of protein aggregation in the adult brain. We demonstrate that Ref(2)P localizes to age-induced protein aggregates as well as to aggregates caused by reduced autophagic or proteasomal activity. A similar localization to protein aggregates is also...

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Identifiers

PMID: 18347073
DOI: 10.1083/jcb.200711108
PMCID: PMC2290837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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