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Article

Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 May 2011

Metlakunta Anantha S, Sahu Maitrayee, Yasukawa Hideo, Dhillon Sandeep S, Belsham Denise D, Yoshimura Akihiko, Sahu Abhiram

Abstract excerpt

Suppressor of cytokine signaling-3 (SOCS3) is thought to be involved in the development of central leptin resistance and obesity by inhibiting STAT3 pathway. Because phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in transducing leptin action in the hypothalamus, we examined whether SOCS3 exerted an inhibition on this pathway. We first determined whether leptin sensitivity in the hypothalamic...

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Source

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Identifiers

PMID: 21325649
DOI: 10.1152/ajpregu.00794.2010
PMCID: PMC3094031

Genes

SOCS3
STAT3
IRS1
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling.PMID 21325649Read ↗

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