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Article

Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity

1 Apr 2013

Abstract excerpt

Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling pathways are critical for the maintenance of homeostatic and developmental processes; however, deregulation and chronic activation of JAK-STAT3 results in numerous diseases. Among others, obesity is currently being intensively studied. In obesity, chronic JAK-STAT3 is activated by the CNS by increased circulating leptin levels...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 24058813
DOI: 10.4161/jkst.23878

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