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Article

Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues

15 Jul 1999

Abstract excerpt

Leptin concentrations are elevated in the majority of obese individuals raising the possibility that leptin resistance contributes to their obesity. Peripheral leptin administration for 48 h caused a several-fold increase in mRNA encoding the suppressors of cytokine signaling SOCS-3 and CIS in hypothalamus and peripheral tissues. Paradoxically, CIS and SOCS-3 mRNAs are also elevated in the leptin-deficient ob/ob...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 10428495
DOI: 10.1016/s0014-5793(99)00874-1

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