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Article

SOCS3 negatively regulates LIF signaling in neural precursor cells.

Molecular and cellular neurosciences - 1 Apr 2006

Emery B, Merson T D, Snell C, Young K M, Ernst M, Kilpatrick T J

Abstract excerpt

Cytokines that signal through the LIFRbeta/gp130 receptor complex, including LIF and CNTF, promote the self-renewal of embryonic and adult neural precursor cells (NPCs). In non-CNS tissues, the protein suppressor of cytokine signaling-3 (SOCS3) negatively regulates signaling through gp130. Here, we analyze the role of SOCS3 in inhibiting LIF signaling in NPCs in vitro. SOCS3 is rapidly expressed by NPCs in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16497512
DOI: 10.1016/j.mcn.2006.01.005

Genes

LIF
SOCS3
CNTF
GFAP
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SOCS3 negatively regulates LIF signaling in neural precursor cells.PMID 16497512Read ↗

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