Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor.

FEBS letters - 1 Dec 2000

Eyckerman S, Broekaert D, Verhee A, Vandekerckhove J, Tavernier J

Abstract excerpt

The leptin system provides a link between adipose mass and the central nervous system. The appetite suppressing effects of leptin are impaired in most obese patients and some mutant mice strains. Herein we describe how suppressor of cytokine signalling 3 (SOCS3), a potential mediator of this leptin resistance is recruited into the activated murine leptin receptor complex. Using a functional assay based on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Chromatography, Affinity
Share to PC12 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphopeptides

Share to Receptors, Leptin

Share to Suppressor of Cytokine Signaling 3 Protein

Share to Suppressor of Cytokine Signaling Proteins

Share to Tyrosine

Source

Identifiers

PMID: 11108838
DOI: 10.1016/s0014-5793(00)02205-5

Genes

SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor.PMID 11108838Read ↗

A complex interaction pattern of CIS and SOCS2 with the leptin receptorSemantic proximity Read ↗

Identification of SOCS-3 as a Potential Mediator of Central Leptin ResistanceSemantic proximity Read ↗

SOCS3Semantic proximity Read ↗

Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.Semantic proximity Read ↗

Leptin signaling.Semantic proximity Read ↗

Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissuesSemantic proximity Read ↗

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.Semantic proximity Read ↗

SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changesSemantic proximity Read ↗

Structure, production and signaling of leptin.Semantic proximity Read ↗

Activation of downstream signals by the long form of the leptin receptor.Semantic proximity Read ↗

Transcriptional and physiological roles for STAT proteins in leptin actionSemantic proximity Read ↗

STAT3 signalling is required for leptin regulation of energy balance but not reproduction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.