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Article

Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis.

International journal of molecular sciences - 3 Dec 2020

Frejborg Ellen, Salo Tuula, Salem Abdelhakim

Abstract excerpt

The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis. Importantly, COX-2 is activated in response to inflammatory stimuli, where it is also believed to promote the development and progression of head and neck cancers (HNC). COX-2 can mediate its protumorigenic effect through various mechanisms, such...

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Identifiers

PMID: 33287464
DOI: 10.3390/ijms21239246
PMCID: PMC7731111

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