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Article

Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015

Blidner Ada G, Salatino Mariana, Mascanfroni Ivan D, Diament Miriam J, Bal de Kier Joffé Elisa, Jasnis Maria A, Klein Slobodanka M, Rabinovich Gabriel A

Abstract excerpt

Myeloid-derived suppressor cells (MDSCs) are key regulatory cells that control inflammation and promote tumor-immune escape. To date, no specific immunomodulatory drug has proven efficacy in targeting the expansion and/or function of these cells in different pathophysiologic settings. In this study, we identified a context-dependent effect of the nonsteroidal anti-inflammatory drug indomethacin (IND) on MDSCs,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

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Identifiers

PMID: 25740944
DOI: 10.4049/jimmunol.1401144

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EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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