Article
High-throughput 454 resequencing for allele discovery and recombination mapping in Plasmodium falciparum.
BMC genomics - 17 Feb 2011
Samarakoon Upeka, Regier Allison, Tan Asako, Desany Brian A, Collins Brendan, Tan John C, Emrich Scott J, Ferdig Michael T
Abstract excerpt
BACKGROUND: Knowledge of the origins, distribution, and inheritance of variation in the malaria parasite (Plasmodium falciparum) genome is crucial for understanding its evolution; however the 81% (A+T) genome poses challenges to high-throughput sequencing technologies. We explore the viability of the Roche 454 Genome Sequencer FLX (GS FLX) high throughput sequencing technology for both whole genome sequencing and...
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