Article
High recombination rates and hotspots in a Plasmodium falciparum genetic cross.
Genome biology - 1 Jan 2011
Jiang Hongying, Li Na, Gopalan Vivek, Zilversmit Martine M, Varma Sudhir, Nagarajan Vijayaraj, Li Jian, Mu Jianbing, Hayton Karen, Henschen Bruce, Yi Ming, Stephens Robert, McVean Gilean, Awadalla Philip, Wellems Thomas E, Su Xin-zhuan
Abstract excerpt
BACKGROUND: The human malaria parasite Plasmodium falciparum survives pressures from the host immune system and antimalarial drugs by modifying its genome. Genetic recombination and nucleotide substitution are the two major mechanisms that the parasite employs to generate genome diversity. A better understanding of these mechanisms may provide important information for studying parasite evolution, immune evasion...
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