Article
Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum.
Genome research - 1 Sept 2016
Miles Alistair, Iqbal Zamin, Vauterin Paul, Pearson Richard, Campino Susana, Theron Michel, Gould Kelda, Mead Daniel, Drury Eleanor, O'Brien John, Ruano Rubio Valentin, MacInnis Bronwyn, Mwangi Jonathan, Samarakoon Upeka, Ranford-Cartwright Lisa, Ferdig Michael, Hayton Karen, Su Xin-Zhuan, Wellems Thomas, Rayner Julian, McVean Gil, Kwiatkowski Dominic
Abstract excerpt
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. Current understanding of parasite evolution is impeded by the fact that a large fraction of the genome is either highly repetitive or highly variable and thus difficult to analyze using short-read sequencing technologies. Here, we describe a resource of deep sequencing...
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