Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus.

British journal of pharmacology - 1 Jul 2011

Dostalek Miroslav, Court Michael H, Yan Bingfang, Akhlaghi Fatemeh

Abstract excerpt

BACKGROUND AND PURPOSE: Patients with diabetes mellitus require pharmacotherapy with numerous medications. However, the effect of diabetes on drug biotransformation is not well understood. Our goal was to investigate the effect of diabetes on liver cytochrome P450 3As, the most abundant phase I drug-metabolizing enzymes in humans. EXPERIMENTAL APPROACH: Human liver microsomal fractions (HLMs) were prepared from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

Share to Cytochrome P-450 CYP3A

Share to Diabetes Mellitus

Share to Microsomes, Liver

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Tandem Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 21323901
DOI: 10.1111/j.1476-5381.2011.01270.x
PMCID: PMC3130941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus.PMID 21323901Read ↗

Prevalence of CYP450 gene variations in patients with type 2 diabetes.Semantic proximity Read ↗

Evaluation of important human CYP450 isoforms and P-glycoprotein phenotype changes and genotype in type 2 diabetic patients, before and after treatment, by using Geneva cocktailSemantic proximity Read ↗

Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity.Semantic proximity Read ↗

Factors influencing midazolam hydroxylation activity in human liver microsomes.Semantic proximity Read ↗

Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans.Semantic proximity Read ↗

Evaluation of important human CYP450 isoforms and P-glycoprotein phenotype changes and genotype in type 2 diabetic patients, before and after intensifying treatment regimen using Geneva cocktail.Semantic proximity Read ↗

Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-glycoprotein Activity using Geneva Cocktail ApproachSemantic proximity Read ↗

CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects.Semantic proximity Read ↗

CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population.Semantic proximity Read ↗

Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.Semantic proximity Read ↗

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans.Semantic proximity Read ↗

The concentration of cyclosporine metabolites is significantly lower in kidney transplant recipients with diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.