Article
Prevalence of CYP450 gene variations in patients with type 2 diabetes.
Clinical laboratory - 1 Jan 2010
Weise A, Prause S, Eidens M, Weber M M, Kann P H, Forst T, Pfützner A
Abstract excerpt
BACKGROUND: Drug degradation in the human organism is driven by detoxification mechanisms that can be affected in their efficiency by genetic mutations. The purpose of this pilot investigation was to investigate whether Type 2 diabetes is associated with mutations in prominent members of the CYP 450 isoenzyme family. METHODS: Genomic DNA was isolated from EDTA blood samples of 203 Caucasian subjects (101 patients...
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