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Article

Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2002

Koch Ina, Weil Regina, Wolbold Renzo, Brockmöller Jürgen, Hustert Elisabeth, Burk Oliver, Nuessler Andreas, Neuhaus Peter, Eichelbaum Michel, Zanger Ulrich, Wojnowski Leszek

Abstract excerpt

The elucidation of the individual contributions of the four CYP3A genes to the overall CYP3A activity has been hampered by similarities in their sequence and function. We investigated the expression of CYP3A mRNA species in the liver and in various other tissues using gene-specific TaqMan probes. CYP3A4 transcripts were the most abundant CYP3A mRNA in each of the 63 white European livers tested and accounted on...

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Identifiers

PMID: 12228187
DOI: 10.1124/dmd.30.10.1108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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