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Article

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12.

Nature biotechnology - 1 May 2009

Hosaka Takeshi, Ohnishi-Kameyama Mayumi, Muramatsu Hideyuki, Murakami Kana, Tsurumi Yasuhisa, Kodani Shinya, Yoshida Mitsuru, Fujie Akihiko, Ochi Kozo

Abstract excerpt

We show that selection of drug-resistant bacterial mutants allows the discovery of antibacterial compounds. Mutant strains of a soil-isolated Streptomyces species that does not produce antibacterials synthesize a previously unknown class of antibacterial, which we name piperidamycin. Overall, 6%...

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PMID: 19396160
DOI: 10.1038/nbt.1538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19396160-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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