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Article

Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase.

Journal of bacteriology - 1 Feb 2009

Talà Adelfia, Wang Guojun, Zemanova Martina, Okamoto Susumu, Ochi Kozo, Alifano Pietro

Abstract excerpt

There is accumulating evidence that the ability of actinomycetes to produce antibiotics and other bioactive secondary metabolites has been underestimated due to the presence of cryptic gene clusters. The activation of dormant genes is therefore one of the most important areas of experimental research for the discovery of drugs in these organisms. The recent observation that several actinomycetes possess two RNA...

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Identifiers

PMID: 19047343
DOI: 10.1128/JB.01311-08
PMCID: PMC2632078

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Source receipt: pubmed, retrieved 7 Sept 2026.

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