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A two years longitudinal study of a transgenic Huntington disease monkey

3 Mar 2014

Abstract excerpt

BACKGROUND: A two-year longitudinal study composed of morphometric MRI measures and cognitive behavioral evaluation was performed on a transgenic Huntington's disease (HD) monkey. rHD1, a transgenic HD monkey expressing exon 1 of the human gene encoding huntingtin (HTT) with 29 CAG repeats regulated by a human polyubiquitin C promoter was used together with four age-matched wild-type control monkeys. This is the...

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PMID: 24581271
DOI: 10.1186/1471-2202-15-36

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