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Article

Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/1 mouse model of Huntington's disease.

PloS one - 1 Jan 2013

Rattray Ivan, Smith Edward J, Crum William R, Walker Thomas A, Gale Richard, Bates Gillian P, Modo Michel

Abstract excerpt

Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6 mouse models of HD express a mutant version of exon 1 HTT and typically develop motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy. Unlike the more commonly used R6/2 mouse line, R6/1 mice have fewer CAG repeats and, subsequently, a less rapid pathological...

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Identifiers

PMID: 24367693
DOI: 10.1371/journal.pone.0084726
PMCID: PMC3868608

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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