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Article

Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/2 mouse model of HD.

PloS one - 1 Jan 2013

Rattray Ivan, Smith Edward, Gale Richard, Matsumoto Kaoru, Bates Gillian P, Modo Michel

Abstract excerpt

Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6/2 mouse model of HD expresses a mutant version of exon 1 HTT and develops motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy. Despite the vast number of studies that have been performed on this model, the association between the molecular and cellular...

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Identifiers

PMID: 23593159
DOI: 10.1371/journal.pone.0060012
PMCID: PMC3617160

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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