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Article

Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.

Biophysical journal - 16 Feb 2011

Ma Li-Juan, Ohmert Iris, Vardanyan Vitya

Abstract excerpt

Controlled opening and closing of an ion-selective pathway in response to changes of membrane potential is a fundamental feature of voltage-gated ion channels. In recent decades, various details of this process have been revealed with unprecedented precision based on studies of prototypic potassium channels. Though current scientific efforts are focused more on a thorough description of voltage-sensor movement,...

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Identifiers

PMID: 21320432
DOI: 10.1016/j.bpj.2010.12.3726
PMCID: PMC3037572

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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