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Article

Voltage-dependent C-type inactivation in a constitutively open K+ channel.

Biophysical journal - 15 Sept 2008

Panaghie Gianina, Purtell Kerry, Tai Kwok-Keung, Abbott Geoffrey W

Abstract excerpt

Most voltage-gated potassium (Kv) channels undergo C-type inactivation during sustained depolarization. The voltage dependence and other mechanistic aspects of this process are debated, and difficult to elucidate because of concomitant voltage-dependent activation. Here, we demonstrate that MinK-KCNQ1 (I(Ks)) channels with an S6-domain mutation, F340W in KCNQ1, exhibit constitutive activation but...

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Source

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Identifiers

PMID: 18567635
DOI: 10.1529/biophysj.108.133678
PMCID: PMC2527255

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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