Article
Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2006
Xu Chun, Macciardi Fabio, Li Peter P, Yoon Il-Sang, Cooke Robert G, Hughes Bronwen, Parikh Sagar V, McIntyre Roger S, Kennedy James L, Warsh Jerry J
Abstract excerpt
Disturbed intracellular calcium (Ca(2+)) homeostasis has been implicated in bipolar disorder (BD). Reduced mRNA levels of the transient receptor potential Ca(2+) permeable channel melastatin type 2, TRPM2, in B lymphoblast cell lines (BLCL) from bipolar I disorder (BD-I) patients showing elevated basal intracellular Ca(2+) ([Ca(2+)](B)), an index of altered intracellular Ca(2+) homeostasis, along with its...
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