Article
Further support for association of the mitochondrial complex I subunit gene NDUFV2 with bipolar disorder.
Bipolar disorders - 1 Feb 2008
Xu Chun, Li Peter P, Kennedy James L, Green Marty, Hughes Bronwen, Cooke Robert G, Parikh Sagar V, Warsh Jerry J
Abstract excerpt
BACKGROUND: The nuclear-encoded mitochondrial complex I subunit gene, NDUFV2, has been implicated in the pathogenesis of bipolar disorder (BD) in Japanese by virtue of association of variants in its promoter with BD and decreased NDUFV2 messenger ribonucleic acid (mRNA) levels in B lymphoblasts (BLCL) in BD patients compared to controls. We sought to determine if these same changes occur in non-Japanese...
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